Bioartificial Liver Manufacturing Methodologies in Comparison to Hepatogenesis

End-stage organ failure is a major global issue, with the liver being second-highest transplanted due to lifestyle choices or other conditions. In field of biomedical engineering, artificial manufacturing has been possible alternative transplants by aiming achieve less immune rejection, more efficient production, and higher accessibility. Of biological methods today, two up-and-coming technologies for include 3D bioprinting decellularized regeneration. By analyzing general stages decellularization development comparing it cellular genetic hepatic in embryo, dilemmas successes bioartificial can be identified. Overall, neither methodology replicate influence non-liver based hepatogenesis. similar hepatogenesis cell construction, but contains shortcomings vascularization, which addressed using vasculogenesis angiogenesis processes development. Decellularization allows differentiation, although unable instill natural distribution gradual ECM This may cause blockages clinical use future. Both have potential application, technology aligned development, proven induce fewer errors physiological nature manufactured liver. future, modification research must conducted on specific these methodologies either create an operational use.